Protein name:
Receptor-interacting serine/threonine-protein kinase 3 ;
Alternative:
Receptor-interacting protein 3 (RIP-3;mRIP3) ;RIP-like protein kinase 3 ;
Organism:
Mouse (Mus musculus).
General Annotation
Sub Unit:
Interacts (via RIP homotypic interaction motif) with RIPK1 (via RIP homotypic interaction motif); this interaction induces RIPK1 phosphorylation and formation of a RIPK1-RIPK3 necroptosis-inducing complex. Binds TRAF2 is recruited to the TNFR-1 signaling complex (By similarity). Interacts with PYGL, GLUL and GLUD1; these interactions result in activation of these metabolic enzymes. Interacts (via RIP homotypic interaction motif) with murid herpesvirus 1 viral inhibitor of RIP activation; this interaction disrupts RIP3-RIP1 interactions characteristic of TNF-alpha induced necroptosis, thereby suppressing this death pathway.
Function:
Essential for cellular necroptosis in response to TNF-alpha family of death-inducing cytokines. Upon induction of necrosis, RIPK3 interacts with, and phosphorylates RIPK1 to form a necrosis-inducing complex. RIPK3 binds to and enhances the activity of three metabolic enzymes: GLUL, GLUD1, and PYGL. These metabolic enzymes may eventually stimulate the tricarboxylic acid cycle and oxidative phosphorylation, which could result in enhanced ROS production.
Subcellular Location:
Cytoplasm
Cell membrane
Mitochondrion
Protein Attributes:
50:
MSSVKLWPTG | ASAVPLVSRE | ELKKLEFVGK | GGFGVVFRAH | HRTWNHDVAV |
100:
KIVNSKKISW | EVKAMVNLRN | ENVLLLLGVT | EDLQWDFVSG | QALVTRFMEN |
150:
GSLAGLLQPE | CPRPWPLLCR | LLQEVVLGMC | YLHSLDPPLL | HRDLKPSNIL |
200:
LDPELHAKLA | DFGLSTFQGG | SQSGSGSGSG | SRDSGGTLAY | LDPELLFKVN |
250:
LKASKASDVY | SFGILVWAVL | AGREAELVDK | TSLIRETVCD | RQSRPPLTEL |
300:
PPGSPETPGL | EKLKELMIHC | WGSQSENRPS | FQDCEPKTNE | VYNLVKDKVD |
350:
AAVSEVKHYL | SQHRSSGRNL | SAREPSQRGT | EMDCPRETMV | SKMLDRLHLE |
400:
EPSGPVPGKC | PERQAQDTSV | GPATPARTSS | DPVAGTPQIP | HTLPFRGTTP |
450:
GPVFTETPGP | HPQRNQGDGR | HGTPWYPWTP | PNPMTGPPAL | VFNNCSEVQI |
486:
GNYNSLVAPP | RTTASSSAKY | DQAQFGRGRG | WQPFHK
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Mouse
Rat
ELISA Kit for Mouse Receptor-interacting serine/threonine-protein kinase 3
ELISA Kit for Mouse Receptor-interacting serine/threonine-protein kinase 3
ELISA Kit for Mouse Receptor-interacting serine/threonine-protein kinase 3
CLIA Kit for Mouse Receptor-interacting serine/threonine-protein kinase 3
CLIA Kit for Mouse Receptor-interacting serine/threonine-protein kinase 3
CLIA Kit for Mouse Receptor-interacting serine/threonine-protein kinase 3
Polyclonal Antibody for Mouse Receptor-interacting serine/threonine-protein kinase 3
Polyclonal Antibody for Mouse Receptor-interacting serine/threonine-protein kinase 3
Polyclonal Antibody for Mouse Receptor-interacting serine/threonine-protein kinase 3
Monoclonal Antibody for Mouse Receptor-interacting serine/threonine-protein kinase 3
Monoclonal Antibody for Mouse Receptor-interacting serine/threonine-protein kinase 3
Monoclonal Antibody for Mouse Receptor-interacting serine/threonine-protein kinase 3
Protein for Mouse Receptor-interacting serine/threonine-protein kinase 3
Protein for Mouse Receptor-interacting serine/threonine-protein kinase 3
Protein for Mouse Receptor-interacting serine/threonine-protein kinase 3
R&D Technical Data
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Precision
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Recovery
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Linearity
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